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the secretagogue hierarchy.

ranking every compound that stimulates the GH axis, and the receptor biology that explains why.

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"every compound on the secretagogue shelf eventually answers to one of two receptors. they don't behave the same."

what's inside
  • →the full class. sermorelin to mk-677, with what each one actually does
  • →where ghrp-6 and ghrp-2 fall, and why ipamorelin replaced both
  • →the cjc-1295 dac vs no-dac question, settled with the half-life data
  • →the most powerful compound in the class, by every metric that matters
  • →the October 2024 PCAC vote and what it changed for anti-aging clinics
  • →the mk-677 chf signal merck never quite published, and the igf-1 cancer epidemiology

one read, ~35 minutes, all sourced. one of many briefs included with $100 lifetime access.

free excerpt

growth hormone secretagogues make your pituitary release more GH than it otherwise would. about a dozen molecules are in commercial use as of 2026, and they sort into two camps because they hit two different receptors. that single fact organizes the whole conversation.

chapters · 18
  1. 01the class, mappedintro
  2. 02the GH axis is a pulse, not a dialbiology
  3. 03the GHRH analogs (the four compounds)class one · overview
  4. 04sermorelin (GHRH 1-29)GHRH analog · fda-approved 1997, withdrawn 2008
  5. 05cjc-1295 no DAC (mod GRF 1-29)GHRH analog · research-chemical · the community workhorse
  6. 06CJC-1295 with DACGHRH analog · 7-day half-life · phase-2 halted 2006
  7. 07tesamorelin (egrifta)GHRH analog · fda-approved · the only one with real long-term data
  8. 08the GHRPs and ghrelin mimetics (the five compounds)class two · overview
  9. 09GHRP-6GHS-R 1a agonist · the original GHRP · D-tier
  10. 10GHRP-2GHS-R 1a agonist · more potent than GHRP-6 · D-tier
  11. 11hexarelinGHS-R 1a agonist · highest peak GH potency · D-tier
  12. 12ipamorelinGHS-R 1a agonist · the clean one · the community standard
  13. 13MK-677 / ibutamorenGHS-R 1a agonist · oral · the CHF signal in elderly
  14. 14why combinations work better than either alonethe stack
  15. 15the hierarchy: ranking the class across every metric that mattersthe ranking
  16. 16the regulatory map and the 2023 inflectionthe legal layer
  17. 17the safety record, the CHF signal, and the IGF-1 cancer questionwhat we know
  18. 18the verdictthe editorial position
who this is for
you're comparing gh-axis options
and the difference between sermorelin, cjc-1295, ipamorelin, tesamorelin, and hgh keeps getting blurred.
you're in a clinic conversation
and you want to know what has trial data, what has regulatory history, and what is mostly anti-aging copy.
you write or trade in this space
and you need the receptor map, the 503A shift, and the safety questions in one sourced document.
you're a clinician
and you want the GH-axis literature without protocol theater or vendor language.
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