BAM15 vs 2,4-dinitrophenol (DNP)

BAM15 (C-tier) vs 2,4-dinitrophenol (DNP) (F-tier). mechanism, trials, evidence boundaries, dosing literature. side-by-side reference.

BAM15 · tier C

a preclinical mitochondrial protonophore that reduced fat gain and improved metabolic measures in mice, with no human exposure, dose-finding, or safety study.

BAM15 has a coherent mechanism and credible mouse metabolic data, but no human bridge and no basis for calling a research-chemical exposure safe.

0 human exposure studies · half-life 1.7 hours in mouse plasma after 10 mg/kg oral gavage; no human half-life · weight loss

2,4-dinitrophenol (DNP) · tier F

DNP is an oral small-molecule mitochondrial uncoupler, not a peptide. People seek it for rapid weight loss. The same mechanism can cause lethal hyperthermia and cardiovascular collapse.

DNP can cause weight loss. Uncontrolled 1930s clinical series reported 2 to 3 pounds weekly, but the same uncoupling has caused fatal hyperthermia and cardiovascular collapse, and no established antidote stops it.

at least 62 published deaths counted in a 2011 medical-literature review · half-life not structured; no routine-use human value · weight loss

at a glance

• BAM15: tier C · 0 human exposure studies
• 2,4-dinitrophenol (DNP): tier F · at least 62 published deaths counted in a 2011 medical-literature review

reptides grades the research record and cites the literature behind every call. research reference only; not medical advice.