BAM15 vs 2,4-dinitrophenol (DNP)
updated
BAM15 (tier C) vs 2,4-dinitrophenol (DNP) (tier F): what each is, half-life and source counts side by side.
BAM15 · tier C
a preclinical mitochondrial protonophore that reduced fat gain and improved metabolic measures in mice, with no human exposure, dose-finding, or safety study.
tier rationale
C-tier reflects a coherent mechanism and a strong integrated mouse paper with oral PK, dose-ranging, metabolic efficacy, and acute tolerability work. It cannot rise to B because no human has been studied, no human PK exists, and the class mechanism carries safety questions that animal temperature measurements cannot settle.
2,4-dinitrophenol (DNP) · tier F
DNP is an oral small-molecule mitochondrial uncoupler, not a peptide. People seek it for rapid weight loss. The same mechanism can cause lethal hyperthermia and cardiovascular collapse.
tier rationale
F tier follows documented weight loss alongside severe and sometimes fatal toxicity, no approved therapeutic use, no established antidote, and no supported self-selected safe range.
at a glance
| BAM15 | 2,4-dinitrophenol (DNP) | |
|---|---|---|
| tier | C | F |
| category | weight loss | weight loss |
| sources | 2 | 7 |
| claims evaluated | 4 | 3 |
| half-life | 1.7 hours in mouse plasma after 10 mg/kg oral gavage; no human half-life | not structured; no routine-use human value |
| dosing data | yes | yes |
reptides grades the research record and cites the literature behind every call. research reference only; not medical advice.