igf-1 lr3 vs hgh
updated
igf-1 lr3 (tier F) vs hgh (tier S): what each is, why each got its grade, half-life and source counts side by side.
igf-1 lr3 · tier F
a free-circulating IGF-1 analog used by bodybuilders chasing muscle growth. sustained IGF-1 elevation carries one of the clearer cancer-risk signals in the literature.
tier rationale
F-tier because the risk profile is qualitatively different from the D-tier compounds. D-tier is 'this doesn't really work' or 'this is obsoleted by a cleaner alternative.' F-tier is 'the mechanism itself carries a specific, well-documented, serious risk that the use case doesn't justify.' IGF-1 LR3 is engineered specifically to bypass the regulatory system that evolution put in place to keep IGF-1 signaling controlled, and IGF-1 elevation is one of the best-characterized cancer risk factors in clinical epidemiology. The muscle-growth benefit is real; so is the risk. The tier reflects the judgment that the calculation doesn't work out.
hgh · tier S
growth hormone. banned in sports, standard at every anti-aging clinic, expensive. works, with trade-offs.
tier rationale
the original anabolic peptide drug. 40+ years of FDA approval across 11+ brand names for pediatric growth failure, adult GHD, HIV wasting, and short bowel syndrome. massive evidence base. criminalized for non-approved uses. one of the most regulated peptides in existence. four decades of pivotal trial evidence. S is the only defensible tier.
at a glance
| igf-1 lr3 | hgh | |
|---|---|---|
| tier | F | S |
| category | gh / growth | gh / growth / weight loss |
| sources | 19 | 20 |
| claims evaluated | 6 | 7 |
| half-life | ~1-2 hours, estimated | ~2-4 hours |
| dosing data | yes | yes |
reptides grades the research record and cites the literature behind every call. research reference only; not medical advice.