melanotan i vs melanotan-ii

melanotan i (C-tier) vs melanotan-ii (A-tier). mechanism, trials, claims vs data, dosing literature. side-by-side reference.

melanotan i — tier C

approved as Scenesse for one rare skin condition. used off-label for tanning. long-term safety, unknown.

Scenesse for erythropoietic protoporphyria (EPP). selective MC1R agonist with a real orphan-drug label. off-label cosmetic use is a different protocol on the same molecule.

FDA '19 Scenesse · EPP · half-life approximately 30 minutes plasma half-life for the free peptide; the approved Scenesse formulation is a controlled-release subcutaneous implant providing roughly 2 months of sustained effect per implant · skin

melanotan-ii — tier A

skin tanning without sun. also triggers sexual arousal. both off-label. both widely used.

tanning without sun. also appetite suppression and sexual arousal. all off-label, all reproducible, and the melanoma case-report literature is real.

RUO not approved · half-life ~30-60 minutes · skin

at a glance

• melanotan i: tier C · FDA '19 Scenesse · EPP
• melanotan-ii: tier A · RUO not approved

reptides grades the research record and cites the literature behind every call. research reference only; not medical advice.