Drostanolone

a historical dromostanolone propionate breast-cancer drug with small human oncology series, no valid systemic half-life, and no current approved human product located.

tier B · androgens · 0 modern systemic human PK studies

verdict

the historical antitumor signal is human evidence, but it is old, small, formulation-specific, and missing the modern PK and safety limbs needed for confidence.

if you are asking what Masteron P means — the medically documented formulation was dromostanolone propionate, an oil-based intramuscular ester sold historically as Drolban. the parent steroid and an unapproved enanthate product cannot inherit its formulation record.

if you are asking for its half-life — no qualifying systemic plasma half-life was located for intramuscular propionate. a 5.3-hour urinary excretion half-life after oral free dromostanolone and a 24-day metabolite detection window are not depot half-lives.

if you are asking whether it was used in humans — yes. historical oncology series used dromostanolone propionate in women with advanced breast cancer. that corrects the claim of zero human exposure, but the studies are not a modern safety dossier.

No number is borrowed from testosterone propionate, drostanolone enanthate vendors, urine excretion, or anti-doping detection.

why B-tier

B tier reflects meaningful but old and uncontrolled human oncology evidence plus a clear historical product identity. Missing modern PK, controlled outcomes, and cardiovascular and endocrine safety data are material limitations.

the core tension

Drostanolone's human oncology history prevents a rodent-only label, but the absence of modern systemic PK, controlled outcomes, and organ-safety data prevents that history from carrying modern confidence.

what it is

Drostanolone, historically named dromostanolone, is a 2-alpha-methyl, 5-alpha-reduced androgen. Drolban contained dromostanolone propionate 50 mg/mL for intramuscular use. This page keeps that ester separate from free oral dromostanolone and unapproved enanthate products.

what it does

The propionate ester releases the parent steroid from an intramuscular oil depot, after which androgen-receptor signaling can inhibit gonadotropins and affect androgen-sensitive tissue. The 5-alpha-reduced A-ring is not an aromatase substrate.

origin

Drolban NDA 012936 was a historical US oncology product. FDA records state that approval was withdrawn effective March 2, 1994.

why researchers are interested

Its reputation is built on non-aromatizing structure and historical use in breast cancer. Neither feature establishes cardiovascular neutrality, a safe cosmetic exposure, or a valid half-life for underground propionate or enanthate products.

does it work

A 1963 series of 20 women with advanced breast cancer reported objective improvement in 6, stable disease in 9, and progression in 5 during dromostanolone propionate treatment. The uncontrolled, small, old record supports B-tier historical human evidence, not a modern efficacy claim.

claims vs the data

• drostanolone propionate has a proven 2-day half-life — unsupported — no qualifying systemic plasma study was located.
• Masteron E inherits Drolban evidence — contradicted — Drolban was the propionate ester; unapproved enanthate material has a different identity and no located clinical PK record.
• drostanolone was never studied in humans — contradicted — historical breast-cancer series exist, although they are small, old, and not modern controlled trials.

key facts

• molecular formula: C23H36O3 (dromostanolone propionate)
• molecular weight: 360.54 g/mol (propionate)
• amino acids: n/a (steroidal small molecule, not a peptide)
• half-life: unknown; no qualifying systemic human or animal plasma half-life for dromostanolone propionate located
• type: 2-alpha-methyl, 5-alpha-reduced androgen; historical intramuscular propionate ester
• CAS: 521-12-0 (dromostanolone propionate)
• 20 patients in a 1963 oncology series
• 6 objective improvements reported
• 0 valid systemic half-life studies located
• 1994 Drolban approval withdrawn

frequently asked questions

Is drostanolone the same as drostanolone propionate?

The parent steroid and its propionate ester are related but not interchangeable for pharmacokinetics. The historical product was dromostanolone propionate in an intramuscular oil formulation.

What is the human half-life?

Unknown for the intramuscular propionate product. Urinary excretion after oral free steroid and anti-doping detection windows do not provide a systemic depot half-life.

Was drostanolone FDA-approved?

Drolban was historically approved. FDA records state that NDA 012936 was withdrawn effective March 2, 1994. No current approved human product was located.

Does non-aromatizing mean safe?

No. It removes one metabolic path, not androgen-receptor suppression, virilization, erythrocytosis, edema, lipid effects, cardiovascular risk, or product-quality risk.

related peptides

• Methenolone — another non-17-alpha-alkylated, non-aromatizing androgen with an older foreign record
• Stanozolol — another DHT-derived androgen, but 17-alpha-alkylated
• testosterone — the human PK and safety comparator

reptides grades the research record and cites the literature behind every call. research reference only; not medical advice.