sermorelin
Sermorelin is amidated GHRH(1-29). Its direct efficacy record is pediatric, while current adult sleep, recovery, and body-composition claims remain unproven.
tier B · growth hormone · 86 efficacy-evaluable children
verdict
People seek sermorelin for sleep, recovery, and body composition. An open-label pediatric study reported faster growth among 86 efficacy-evaluable children, not those adult outcomes.
the core tension
Sermorelin has real pediatric and historical product evidence, but current adult wellness use changes the population, product, and evidence question.
what it is
Sermorelin is the amidated 29-amino-acid fragment of human growth-hormone-releasing hormone. Historical Geref products used sermorelin acetate, while a current compounded vial is a separate product whose identity cannot be assumed from the old label.
what it does
It activates the pituitary GHRH receptor and produces a brief growth-hormone release signal. In an intravenous human study, sermorelin disappeared with a half-time of 4.3 plus or minus 1.4 minutes.
origin
FDA withdrew the historical Geref approvals effective in 2009. In 2013, FDA determined that withdrawal was not for reasons of safety or effectiveness. That history does not create a current approved product.
does it work
The multicenter open-label study treated 110 prepubertal children; 86 were efficacy-evaluable. Mean height velocity in that group rose from 4.1 centimeters per year before treatment to 8.0 at six months and 7.2 at twelve months. Without a comparator, this result does not establish adult sleep, recovery, or body-composition benefit.
key facts
- molecular formula: C149H246N44O42S
- molecular weight: 3357.9 Da base
- amino acids: 29
- half-life: 4.3 plus or minus 1.4 minutes after intravenous administration
- type: amidated GHRH(1-29) peptide
- 86 efficacy-evaluable children
- 4.3 min human IV disappearance half-time
- 2009 historical approvals withdrawn
frequently asked questions
What is sermorelin?
It is amidated GHRH(1-29), historically sold in distinct intravenous diagnostic and subcutaneous pediatric products.
Does sermorelin improve adult sleep or body composition?
That has not been established in a controlled exact-compound adult outcome trial. The strongest direct efficacy study was pediatric.
Is sermorelin currently FDA approved?
No current FDA-approved sermorelin product is identified. Historical Geref approvals were withdrawn, and FDA later determined that the withdrawal was not for safety or effectiveness reasons.
related peptides
- ipamorelin: different receptor and different human record
- sermorelin + GHRP-2: exact acute combination record
reptides grades the research record and cites the literature behind every call. research reference only; not medical advice.