Methandienone vs Oxymetholone

Methandienone (B-tier) vs Oxymetholone (S-tier). mechanism, trials, claims vs data, dosing literature. side-by-side reference.

Methandienone — tier B

an oral 17-alpha-methyl androgen with an old controlled weightlifter trial, withdrawn US approvals for lack of substantial efficacy evidence, and no validated systemic half-life.

an old placebo-controlled trial shows weight and performance effects with frequent adverse effects, while systemic PK, modern efficacy, and contemporary safety evidence remain absent.

13 experienced weightlifters in a placebo-controlled trial · half-life unknown; no qualifying systemic plasma half-life located · androgens

Oxymetholone — tier S

an oral 17-alpha-alkylated anemia drug with legal FDA approval but no active US marketing, controlled human lean-mass data, severe dose-related hepatic toxicity, and animal-only terminal half-life.

oxymetholone has clear human anabolic and wasting outcomes, and those same trials document a severe hepatic and lipid cost that cannot be separated from the evidence grade.

+4.2 kg lean body mass at 100 mg/day in one 12-week RCT · half-life no validated human terminal half-life; 5.56 hours in male F344/N rats after 30 mg/kg oral gavage · androgens

at a glance

• Methandienone: tier B · 13 experienced weightlifters in a placebo-controlled trial
• Oxymetholone: tier S · +4.2 kg lean body mass at 100 mg/day in one 12-week RCT

reptides grades the research record and cites the literature behind every call. research reference only; not medical advice.