Methandienone vs Oxymetholone
updated
Methandienone (tier B) vs Oxymetholone (tier S): what each is, why each got its grade, half-life and source counts side by side.
Methandienone · tier B
an oral 17-alpha-methyl androgen with an old controlled weightlifter trial, withdrawn US approvals for lack of substantial efficacy evidence, and no validated systemic half-life.
tier rationale
B tier reflects a real controlled human performance study and a clear historical drug identity. Small sample size, old methods, efficacy-based approval withdrawal, no modern safety program, and no systemic PK are major limitations.
Oxymetholone · tier S
an oral 17-alpha-alkylated anemia drug with legal FDA approval but no active US marketing, controlled human lean-mass data, severe dose-related hepatic toxicity, and animal-only terminal half-life.
tier rationale
S tier reflects clear identity, an FDA-reviewed label, and multiple controlled human outcome datasets. Severe hepatic and lipid toxicity, discontinued marketing, and missing human terminal PK are stated as central facts, not hidden by the grade.
at a glance
| Methandienone | Oxymetholone | |
|---|---|---|
| tier | B | S |
| category | androgens / anabolics | androgens / anabolics |
| sources | 7 | 7 |
| claims evaluated | 3 | 3 |
| half-life | unknown; no qualifying systemic plasma half-life located | no validated human terminal half-life; 5.56 hours in male F344/N rats after 30 mg/kg oral gavage |
| dosing data | yes | yes |
reptides grades the research record and cites the literature behind every call. research reference only; not medical advice.