I originally ran Mots-c solo along side Reta for 4 months and then took 8 weeks off. I am currently running 2mg Mots-C w/ 2mg SS31 and plan on running this till the end of month. At that time I'll decide if I want to continue or not. I'm not seeing the "energy" I noticed when I first ran Mots-C during my first 3 months of Reta, so it may not be worth the money to continue. Rather wait until early '27 for another cycle.
Not using GLP3, using GLP2.
I started a MotsC blend last week. On a MWF routine as most research has pointed at. Ive tried to not lift on those days. Sadly I have not noticed any bump in performance and energy. Actually on one of those days I had a Celsius that did more for me later in afternoon I was dragging so hard.
I did notice on the day I did a 9 mile run the morning of one I had unusual HR spikes randomly even though my RPE was low. Now, that could have been any number of things; Heat, humidity, sun exposure. Was a hot sunny Florida day, BUT I have done similar runs before that and equally hydrated, so only real factor I can ID is the blend
The blend I have is 100mg NAD+ 10mg MOTS-C 10mg 5-Amino-1MQ
↳ replying to Solar WaxwingOh. I forgot to mention, I think my RHR is up. I usually am sub 60 but currently around 68 bpm. Ive read that Mots changes energy utilization which I have also read is similar to the glycogen component of GLP3. Connection?
↳ replying to Solar WaxwingNo expert but 10mg in one shot? That seems crazy high but we all figuring this out
Interesting article
https://mindandmatter.substack.com/p/metabolic-stress-and-mots-c-how-much?r=y2xn5
↳ replying to Scarlet SanderlingNoooo. That is the ratio of the Blend.
Did MOTS-C solo with Reta 2 mg 3-4/week for a trial month cycle. Noticed significantly improved energy with both cardio and lifting, mostly towards end of workout. Felt like I wanted to keep going after 1.5 hours, had to force myself to stop. Tried NAD+ solo and haven’t noticed much so far. Same goes for SS-31. Prob going to go back to Mots-C for a couple months.
The welts really suck! Didn’t start until a few weeks in for me. Going to try IM in delt to see if that helps.
But to answer your question I’m taking 2-3 weeks off, but it was a quick cycle to see how I liked it.