Finasteride vs Dutasteride

Finasteride (S-tier) vs Dutasteride (A-tier). mechanism, trials, evidence boundaries, dosing literature. side-by-side reference.

Finasteride · tier S

Finasteride is an oral type-II 5-alpha-reductase inhibitor with an FDA-approved male-pattern-hair-loss indication in men and large randomized hair-count trials.

Oral finasteride 1 mg slows progression and improves measured scalp-hair outcomes in men with androgenetic alopecia while treatment continues. That record does not transfer to compounded topical products, women, children, or every pattern of hair loss.

+107 hairs placebo-adjusted one-year vertex-area difference · half-life about 5 to 6 h in adults aged 18 to 60 after oral tablets; longer in older adults · skin

Dutasteride · tier A

Dutasteride inhibits type-I and type-II 5-alpha-reductase. Two randomized oral trials support male androgenetic-alopecia outcomes, but US Avodart approval is for BPH, not hair loss.

Oral dutasteride 0.5 mg improved measured hair outcomes in two six-month male alopecia trials and beat finasteride on specified 24-week endpoints in one. It is not FDA approved for hair loss, and the results do not transfer to topical or injected products.

917 men in the active-comparator alopecia trial · half-life about 5 weeks at steady state after oral Avodart exposure · skin

at a glance

• Finasteride: tier S · +107 hairs placebo-adjusted one-year vertex-area difference
• Dutasteride: tier A · 917 men in the active-comparator alopecia trial

reptides grades the research record and cites the literature behind every call. research reference only; not medical advice.