hcg vs gonadorelin

hcg (S-tier) vs gonadorelin (C-tier). mechanism, trials, claims vs data, dosing literature. side-by-side reference.

hcg — tier S

a pregnancy hormone with real fertility labels and a major off-label TRT-adjunct story.

an old pregnancy hormone. fertility labels in front, decades of off-label TRT-adjunct practice behind them.

legacy Pregnyl + Novarel · pre-1962 NDA · half-life ~36 hours · libido

gonadorelin — tier C

synthetic GnRH. historical human use, current US labels are animal-drug products, and TRT-clinic use is its own off-label lane.

synthetic GnRH. historical Lutrepulse approval, current US labels are animal-drug products, and TRT-clinic use is a separate off-label lane.

FDA '82 Factrel · diag · half-life extremely short, 2-4 minutes in plasma. The primary practical limitation of the compound. Clinical use for ovulation induction historically required pulsatile IV delivery via pump. · libido

at a glance

• hcg: tier S · legacy Pregnyl + Novarel · pre-1962 NDA
• gonadorelin: tier C · FDA '82 Factrel · diag

reptides grades the research record and cites the literature behind every call. research reference only; not medical advice.