kisspeptin-10 vs gonadorelin
updated
kisspeptin-10 (tier B) vs gonadorelin (tier C): what each is, why each got its grade, half-life and source counts side by side.
kisspeptin-10 · tier B
kisspeptin-family pharmacology with real HSDD and fertility signals. the strongest human trials used kisspeptin-54, not the KP-10 vial market.
tier rationale
B-tier because the clinical research around the kisspeptin pathway is real and rigorous but the regulatory pipeline is still early, and because KP-10 is not the exact molecule used in the strongest HSDD and IVF trials. Imperial College trials give drug-grade evidence at small scale, published in JAMA Network Open, for a clinically meaningful condition. Held back from A by the absence of phase 3 data, no FDA filing pending, and the molecule-identity gap between KP-54 trials and KP-10 market supply.
gonadorelin · tier C
Native-sequence GnRH with real historical pump and diagnostic uses. Pulse timing determines whether the signal works.
tier rationale
Human efficacy is real when gonadorelin is delivered as a physiologic pulse. The common TRT substitution claim uses a different schedule and lacks a controlled outcome trial.
at a glance
| kisspeptin-10 | gonadorelin | |
|---|---|---|
| tier | B | C |
| category | sexual / hormonal | sexual / hormonal |
| sources | 23 | 12 |
| claims evaluated | 6 | 2 |
| half-life | short, approximately 4-5 minutes in plasma | about 4 minutes after intravenous administration |
| dosing data | yes | yes |
reptides grades the research record and cites the literature behind every call. research reference only; not medical advice.