BAM15 vs 5-amino-1mq
updated
BAM15 (tier C) vs 5-amino-1mq (tier C): what each is, why each got its grade, half-life and source counts side by side.
BAM15 · tier C
a preclinical mitochondrial protonophore that reduced fat gain and improved metabolic measures in mice, with no human exposure, dose-finding, or safety study.
tier rationale
C-tier reflects a coherent mechanism and a strong integrated mouse paper with oral PK, dose-ranging, metabolic efficacy, and acute tolerability work. It cannot rise to B because no human has been studied, no human PK exists, and the class mechanism carries safety questions that animal temperature measurements cannot settle.
5-amino-1mq · tier C
5-amino-1MQ is a small molecule NNMT inhibitor, not a peptide. People seek it for fat loss, but every administration and outcome study located for this review was in animals.
tier rationale
C-tier preserves the real mouse efficacy and pharmacokinetic record while marking the decisive boundary: no study located for this review administered the compound to people.
at a glance
| BAM15 | 5-amino-1mq | |
|---|---|---|
| tier | C | C |
| category | weight loss | weight loss |
| sources | 2 | 13 |
| claims evaluated | 4 | 3 |
| half-life | 1.7 hours in mouse plasma after 10 mg/kg oral gavage; no human half-life | no human pharmacokinetic measurement; rat and mouse values differ by route and are kept separate |
| dosing data | yes | yes |
reptides grades the research record and cites the literature behind every call. research reference only; not medical advice.