5-amino-1mq vs mots-c
updated
5-amino-1mq (tier C) vs mots-c (tier B): what each is, why each got its grade, half-life and source counts side by side.
5-amino-1mq · tier C
5-amino-1MQ is a small molecule NNMT inhibitor, not a peptide. People seek it for fat loss, but every administration and outcome study located for this review was in animals.
tier rationale
C-tier preserves the real mouse efficacy and pharmacokinetic record while marking the decisive boundary: no study located for this review administered the compound to people.
mots-c · tier B
mitochondrial peptide your body makes during exercise. restores metabolic health in mice. never given to a person in a trial.
tier rationale
B-tier because the preclinical evidence is genuinely novel and interesting (mitochondrial-encoded peptide, exercise-induced, age-declining, aging-reversing in mice), but parent-molecule human results have not read out. Not C-tier because the mechanism is well-characterized and the animal data is extensive. Not A-tier because the jump from mouse to human requires completed clinical testing. MOTS-c sits in an unusual category: exceptional biology, and a therapeutic record that has not begun.
at a glance
| 5-amino-1mq | mots-c | |
|---|---|---|
| tier | C | B |
| category | weight loss | nootropic / longevity / weight loss |
| sources | 13 | 26 |
| claims evaluated | 3 | 6 |
| half-life | no human pharmacokinetic measurement; rat and mouse values differ by route and are kept separate | minutes in plasma; functional effects persist hours via downstream gene expression |
| dosing data | yes | yes |
reptides grades the research record and cites the literature behind every call. research reference only; not medical advice.