liraglutide vs semaglutide
updated
liraglutide (tier S) vs semaglutide (tier S): what each is, half-life and source counts side by side.
liraglutide · tier S
A once-daily GLP-1 receptor agonist sold under separate Saxenda and Victoza labels.
tier rationale
S reflects approved uses, the 3,731-person SCALE weight-management trial, and the 9,340-person LEADER cardiovascular-outcomes trial. Saxenda and Victoza use different target exposures and evidence packages.
semaglutide · tier S
A GLP-1 receptor agonist with current US injection and oral products for distinct labeled uses.
tier rationale
The S tier reflects large randomized trials showing weight-loss, cardiovascular, and kidney benefits in the studied populations, plus positive biopsy outcomes in a planned phase 3 liver-disease interim analysis.
at a glance
| liraglutide | semaglutide | |
|---|---|---|
| tier | S | S |
| category | weight loss | weight loss |
| sources | 9 | 16 |
| claims evaluated | n/a | n/a |
| half-life | ~13 hours | ~1 week |
| dosing data | yes | yes |
reptides grades the research record and cites the literature behind every call. research reference only; not medical advice.