liraglutide vs semaglutide

liraglutide (S-tier) vs semaglutide (S-tier). mechanism, trials, claims vs data, dosing literature. side-by-side reference.

liraglutide — tier S

the first GLP-1 weight loss drug. saxenda and victoza. now outclassed by semaglutide and tirzepatide.

the first GLP-1 for weight loss. saxenda for obesity, victoza for T2D. outclassed by semaglutide and tirzepatide now, but still on the shelf and still labeled.

FDA '14 Saxenda · obesity · half-life ~13 hours · weight loss

semaglutide — tier S

ozempic. wegovy. rybelsus. the GLP-1 drug that made obesity a pharmacology problem.

the GLP-1 that broke containment. ozempic, wegovy, rybelsus. same molecule, three labels.

14.9% STEP 1 wt loss · half-life ~1 week (acylated) · weight loss

at a glance

• liraglutide: tier S · FDA '14 Saxenda · obesity
• semaglutide: tier S · 14.9% STEP 1 wt loss

reptides grades the research record and cites the literature behind every call. research reference only; not medical advice.