tesamorelin vs sermorelin
updated
tesamorelin (tier S) vs sermorelin (tier B): what each is, half-life and source counts side by side.
tesamorelin · tier S
the FDA-approved injection that targets visceral fat. the dangerous kind.
tier rationale
different mechanism than GLP-1s. tesa tells your pituitary to pulse growth hormone, which mobilizes visceral fat. clean, targeted, documented. FDA-approved since 2010 for HIV-associated lipodystrophy. long-term cardiovascular safety still uncertain. increasingly used off-label by men 40+ for body recomp. S because drug-tier human trial data exists. narrow indication and high cost keep it niche.
sermorelin · tier B
Sermorelin is amidated GHRH(1-29). Its direct efficacy record is pediatric, while current adult sleep, recovery, and body-composition claims remain unproven.
tier rationale
The B grade reflects pediatric growth studies, diagnostic hormone responses, and human pharmacokinetics. Historic products were withdrawn, and controlled adult wellness outcomes have not been established.
at a glance
| tesamorelin | sermorelin | |
|---|---|---|
| tier | S | B |
| category | weight loss / gh / growth | gh / growth |
| sources | 28 | 11 |
| claims evaluated | 8 | n/a |
| half-life | ~8-11 minutes | 4.3 plus or minus 1.4 minutes after intravenous administration |
| dosing data | yes | yes |
reptides grades the research record and cites the literature behind every call. research reference only; not medical advice.