tesamorelin vs sermorelin
tesamorelin (S-tier) vs sermorelin (B-tier). mechanism, trials, evidence boundaries, dosing literature. side-by-side reference.
tesamorelin · tier S
the FDA-approved injection that targets visceral fat. the dangerous kind.
the only adult-labeled GHRH analog. FDA-approved for visceral fat reduction in HIV-associated lipodystrophy. the label says it's not a weight-loss drug.
15-18% VAT reduction · half-life ~26-38 minutes (subQ) · weight loss
sermorelin · tier B
Sermorelin is amidated GHRH(1-29). Its direct efficacy record is pediatric, while current adult sleep, recovery, and body-composition claims remain unproven.
People seek sermorelin for sleep, recovery, and body composition. An open-label pediatric study reported faster growth among 86 efficacy-evaluable children, not those adult outcomes.
86 efficacy-evaluable children · half-life 4.3 plus or minus 1.4 minutes after intravenous administration · growth hormone
at a glance
- tesamorelin: tier S · 15-18% VAT reduction
- sermorelin: tier B · 86 efficacy-evaluable children
reptides grades the research record and cites the literature behind every call. research reference only; not medical advice.