sermorelin vs ipamorelin
updated
sermorelin (tier B) vs ipamorelin (tier C): what each is, half-life and source counts side by side.
sermorelin · tier B
Sermorelin is amidated GHRH(1-29). Its direct efficacy record is pediatric, while current adult sleep, recovery, and body-composition claims remain unproven.
tier rationale
The B grade reflects pediatric growth studies, diagnostic hormone responses, and human pharmacokinetics. Historic products were withdrawn, and controlled adult wellness outcomes have not been established.
ipamorelin · tier C
Ipamorelin is a synthetic pentapeptide ghrelin-receptor agonist. People seek it for sleep, recovery, and body composition, but direct human studies measured an acute intravenous GH pulse and a negative ileus outcome.
tier rationale
C reflects dose-related human growth-hormone release plus a 114-person clinical efficacy trial that missed its primary endpoint. No controlled study measured the marketed fitness, recovery, or sleep outcomes.
at a glance
| sermorelin | ipamorelin | |
|---|---|---|
| tier | B | C |
| category | gh / growth | gh / growth |
| sources | 11 | 11 |
| claims evaluated | n/a | n/a |
| half-life | 4.3 plus or minus 1.4 minutes after intravenous administration | about 2 hours after intravenous infusion |
| dosing data | yes | yes |
reptides grades the research record and cites the literature behind every call. research reference only; not medical advice.