tesamorelin vs ipamorelin
updated
tesamorelin (tier S) vs ipamorelin (tier C): what each is, half-life and source counts side by side.
tesamorelin · tier S
the FDA-approved injection that targets visceral fat. the dangerous kind.
tier rationale
different mechanism than GLP-1s. tesa tells your pituitary to pulse growth hormone, which mobilizes visceral fat. clean, targeted, documented. FDA-approved since 2010 for HIV-associated lipodystrophy. long-term cardiovascular safety still uncertain. increasingly used off-label by men 40+ for body recomp. S because drug-tier human trial data exists. narrow indication and high cost keep it niche.
ipamorelin · tier C
Ipamorelin is a synthetic pentapeptide ghrelin-receptor agonist. People seek it for sleep, recovery, and body composition, but direct human studies measured an acute intravenous GH pulse and a negative ileus outcome.
tier rationale
C reflects dose-related human growth-hormone release plus a 114-person clinical efficacy trial that missed its primary endpoint. No controlled study measured the marketed fitness, recovery, or sleep outcomes.
at a glance
| tesamorelin | ipamorelin | |
|---|---|---|
| tier | S | C |
| category | weight loss / gh / growth | gh / growth |
| sources | 28 | 11 |
| claims evaluated | 8 | n/a |
| half-life | ~26-38 minutes | about 2 hours after intravenous infusion |
| dosing data | yes | yes |
reptides grades the research record and cites the literature behind every call. research reference only; not medical advice.