humanin vs mots-c
humanin (C-tier) vs mots-c (B-tier). mechanism, trials, claims vs data, dosing literature. side-by-side reference.
humanin — tier C
a 24-amino-acid peptide your mitochondria encode. cytoprotective and metabolic biology in cells and rodents. zero interventional human trials.
the first mitochondrial-derived peptide ever described. real, replicated cytoprotective and metabolic biology in cell and rodent models. no completed interventional human trial.
24 aa mitochondrial-derived · half-life short in plasma (minutes); analogs were engineered for greater stability, downstream signaling effects persist longer · focus
mots-c — tier B
mitochondrial peptide your body makes during exercise. restores metabolic health in mice. human trials just starting.
a mitochondrial-derived peptide. AMPK activation, mouse data is strong and replicated. the first-in-human parent-molecule trial just started April 2026.
16 aa mitochondrial-derived · half-life minutes in plasma; functional effects persist hours via downstream gene expression · focus
at a glance
reptides grades the research record and cites the literature behind every call. research reference only; not medical advice.