NAD+ vs mots-c
NAD+ (B-tier) vs mots-c (B-tier). mechanism, trials, evidence boundaries, dosing literature. side-by-side reference.
NAD+ · tier B
not a peptide. the cofactor your mitochondria run on. IV drips are the longevity-clinic staple despite thin clinical evidence.
not a peptide. the cofactor your mitochondria run on. the IV drip is the longevity-clinic staple; the oral precursors have most of the actual evidence.
half-life IV: rapid cellular uptake; oral precursors (NMN, NR): hours; endogenous NAD+ cycling: minutes to hours depending on tissue · focus
mots-c · tier B
mitochondrial peptide your body makes during exercise. restores metabolic health in mice. never given to a person in a trial.
a mitochondrial-derived peptide. AMPK activation, mouse data is strong and replicated. no trial has ever given it to a person, and the one registry record saying otherwise is fabricated.
16 aa mitochondrial-derived · half-life minutes in plasma; functional effects persist hours via downstream gene expression · focus
at a glance
reptides grades the research record and cites the literature behind every call. research reference only; not medical advice.