mots-c vs SLU-PP-332
updated
mots-c (tier B) vs SLU-PP-332 (tier C): what each is, why each got its grade, half-life and source counts side by side.
mots-c · tier B
mitochondrial peptide your body makes during exercise. restores metabolic health in mice. never given to a person in a trial.
tier rationale
B-tier because the preclinical evidence is genuinely novel and interesting (mitochondrial-encoded peptide, exercise-induced, age-declining, aging-reversing in mice), but parent-molecule human results have not read out. Not C-tier because the mechanism is well-characterized and the animal data is extensive. Not A-tier because the jump from mouse to human requires completed clinical testing. MOTS-c sits in an unusual category: exceptional biology, and a therapeutic record that has not begun.
SLU-PP-332 · tier C
SLU-PP-332 is a small-molecule pan-ERR agonist with mouse endurance and metabolic results, ex vivo human myoblast work, no oral bioavailability, and no human administration study.
tier rationale
C-tier reflects direct and repeated preclinical findings with no human administration evidence.
at a glance
| mots-c | SLU-PP-332 | |
|---|---|---|
| tier | B | C |
| category | nootropic / longevity / weight loss | weight loss |
| sources | 26 | 12 |
| claims evaluated | 6 | 3 |
| half-life | minutes in plasma; functional effects persist hours via downstream gene expression | no numeric human or animal concentration-time curve retained |
| dosing data | yes | yes |
reptides grades the research record and cites the literature behind every call. research reference only; not medical advice.