ipamorelin vs ghrp-2

updated October 25, 2026

ipamorelin (tier C) vs ghrp-2 (tier D): what each is, half-life and source counts side by side.

ipamorelin · tier C

Ipamorelin is a synthetic pentapeptide ghrelin-receptor agonist. People seek it for sleep, recovery, and body composition, but direct human studies measured an acute intravenous GH pulse and a negative ileus outcome.

tier rationale

C reflects dose-related human growth-hormone release plus a 114-person clinical efficacy trial that missed its primary endpoint. No controlled study measured the marketed fitness, recovery, or sleep outcomes.

ghrp-2 · tier D

first-gen GH releaser. raises GH in short human studies. also spikes cortisol, prolactin, and hunger. ipamorelin replaced it.

tier rationale

D-tier because a cleaner alternative, ipamorelin, exists with the same core receptor target and less cortisol/prolactin baggage. Not F-tier because GHRP-2 works, it is a legitimate compound with a real mechanism and real effects, just worse than its direct successor for most GH-axis use cases. This is obsolete tier, not broken tier. With ipamorelin available as the cleaner comparator, the remaining niche is appetite stimulation rather than superior GH-axis signaling.

at a glance

reptides grades the research record and cites the literature behind every call. research reference only; not medical advice.