Ibutamoren vs ipamorelin

Ibutamoren (D-tier) vs ipamorelin (C-tier). mechanism, trials, evidence boundaries, dosing literature. side-by-side reference.

Ibutamoren · tier D

Ibutamoren is an unapproved oral ghrelin-receptor agonist that raises endogenous GH and IGF-1. Older-adult trials found a lean-mass signal without a reliable strength or function benefit.

Oral MK-677 increased GH, IGF-1, and fat-free mass in selected older adults, but strength and most function measures did not improve. The record does not establish athletic, recovery, anti-aging, or longevity benefit.

+1.1 kg year-one fat-free-mass change in one older-adult trial · half-life not stated; no qualifying public base PK set in the cited pivotal human reports · growth hormone

ipamorelin · tier C

Ipamorelin is a synthetic pentapeptide ghrelin-receptor agonist. People seek it for sleep, recovery, and body composition, but direct human studies measured an acute intravenous GH pulse and a negative ileus outcome.

Ipamorelin released GH after intravenous infusion, but it has no controlled human sleep, recovery, muscle, or body-composition outcome trial. Its selectivity case comes mainly from swine and rodent work.

114 patients in the negative ileus trial · half-life about 2 hours after intravenous infusion · growth hormone

at a glance

• Ibutamoren: tier D · +1.1 kg year-one fat-free-mass change in one older-adult trial
• ipamorelin: tier C · 114 patients in the negative ileus trial

reptides grades the research record and cites the literature behind every call. research reference only; not medical advice.